Dramatic video footage emerged showing the TransAsia Airways plane clipping a bridge as it came down shortly after take-off from a Taipei airport.
The plane, carrying 58 people, broke up as it plunged into Taipei's Keelung River. The fuselage was later salvaged by crane.
There were 15 survivors pulled from the wreckage but 12 people remain missing.
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Television footage showed some passengers wading clear of the sunken wreckage and a toddler being pulled out alive by rescuers.
Emergency teams cut open the plane while it was in the water but were unable to reach the passengers trapped in the front section of the fuselage.
As night fell, a crane was used to lift the wreckage on to the bank. The death toll was expected to rise as rescue teams searched the fuselage and the river for the 12 missing passengers.
"At the moment, things don't look too optimistic," Wu Jun-hong, a Taipei fire department official coordinating the rescue effort told reporters.